Thinking / remembering further - when the Gene was released for AM5, I'd wondered whether the optimized two-DIMM configuration would be useful; the first AM5 CPUs (the current 7000-series) were simply unable to broadly support memory speeds above 6000MT/s, and for those CPUs that's still the recommended target speed.
But like the 5000G-series before, the monolithic die in the 8000G-series seems to come with a memory controller that's relatively unconstrained. Personally, I had no problem running DDR4 4400+ on a 5700G and an ITX board (two DIMM slots like the Gene), where the chiplet-based CPUs rarely managed to hit above DDR4 3800+.
This also implies that the memory configurations on the nicer AM5 boards probably do / did inherit the lessons learned from the Z690 boards, meaning that as AMDs DDR5 memory controllers mature, much higher memory speeds and denser memory configurations (like 192GB with 4x 48GB DIMMs) might be possible.
